Fundación Jacinto Convit

Leishmaniasis


Introduction

Leishmaniasis is a disease found in the tropical jungles of America, as well as in Asia and Africa. Actually, leishmaniasis is a group of diseases caused by different species of the Leishmania parasite, which is divided, according to the medical point of view, into superficial leishmaniasis that mainly affects the skin and mucous membranes, and visceral leishmaniasis, also called kala-azar, that harms the internal organs (liver, spleen, bone marrow). This disease is potentially fatal if left untreated.

Leishmaniasis can be divided into three groups:

  • Cutaneous leishmaniasis (CL) causes nodules on the skin infected with the parasite.

  • Mucocutaneous Leishmaniasis (MCL) causes ulcers and erodes the mucous membranes and cartilage.

  • Visceral Leishmaniasis (VL) is a severe form in which the parasite migrates to the vital organs.

This disease is a serious public health problem, because like Chagas disease, it generates a high rate of morbidity and mortality in the population. Currently, there are approximately 12 million people infected with Leishmaniasis worldwide, however many cases are never reported. Leishmaniasis belongs to the group of diseases associated with poverty, mainly because the people who are infected live in remote areas, but also because they suffer a social stigma due to the facial disfigurement or very noticeable scars caused by this disease. Ultimately, these people suffer permanent psychological damage that impels them to remain hidden. This means that although superficial leishmaniasis is not usually fatal, it can cause the patient's social death.

Dr. Convit's Studies

In 1968, Dr. Jacinto Convit joins research groups to study Leishmaniasis. During his research, he demonstrates that when Cutaneous Leishmaniasis (CL) develops, there is an immunological defect of the patient. This defect was determined to be more related to the disease than other aspects such as the parasite variations, adaptations or mutations, without denying the obvious effect of different parasite strains and other particular features of the parasite. Assuming this concept, of a defect in the immunological system of the patient when developing CL, Dr. Convit started searching preventive methods against the disease and insisted that the patient and his living environment had to be accurately evaluated. This led Dr. Convit to advise international institutions that Leishmaniasis was more than a forgotten disease, as it was known, it was a disease of forgotten people, who lack of good and proper attention. This aimed to develop a new perspective of the health system.

Additionally, Dr. Convit's vision on this new concept of CL development, led him to use the leprosy vaccine as a model to develop a vaccine for Leishmaniasis. So he used a mix of dead Leishmania promastigotes harvested from in vitro cultured parasites plus viable BCG. The effectiveness of the vaccine was mainly evaluated in the localized CL form (LCL), as this was the most frequent form of the disease and the most probable to show an adequate immunological response of the patient to the immunotherapy. Between 1990 and 1999, the experimental application of the vaccine in Venezuela on patients with diagnosed CL, gave rise to the cure of most of the patients, a total success. Hence, a very unexpensive and with no secondary effects vaccine was created, contrary to the chemical drugs that were used.

Role of the Foundation

The main objective of the Foundation is to support the massification and distribution of Dr. Convit's vaccine against leishmaniasis in Venezuela and in other countries affected by this disease, such as Central American countries where Dr. Convit was already applying his vaccine and seeing excellent results.

Additionally, the Foundation aims to include testing of this disease under its Molecular Diagnostic Unit in order to contribute to an early and personalized diagnose of the affected population. At the same time, the Foundation aims to develop new lines of research in this area that include molecular epidemiological studies of the parasites, as well as other therapeutic alternatives for the disease.

Information for Patients

¿How do people get Leishmaniasis?

The protozoan parasite is transmitted by the bite of the sand fly or phlebotome of the genus Phlebotomus or Lutzomyia. These insects inhabit humid areas where the average temperature is 20 C, and usually bite any exposed area of the body. Transmission occurs when a sand fly bites an infected mammal, and the now infected sandfly innoculates the parasites into a healthy host through its bite when it tries to feed on the host's blood.

Phlebotomus or Lutzomyia

There are different forms of leishmaniasis:

Cutaneous leishmaniasis affects the skin and mucous membranes. Skin sores usually start at the site of the sandfly bite and can last months or years before they heal by themselves. In a few people, sores may develop on mucous membranes.

Systemic, or visceral, leishmaniasis affects the entire body. This form develops in 2 to 8 months after a person is bitten by the sandfly. Most people do not remember having a skin sore. This form can lead to deadly complications if left untreated. The parasites damage the immune system by decreasing the numbers of disease-fighting cells, thus further weakening the patient.

¿How is Leishmaniasis treated?

The main drugs used to treat leishmaniasis are antimony-containing compounds which include Meglumine antimoniate, Sodium stibogluconate.

However, the immunotherapy or vaccine designed by Dr. Convit, has proven equally effective as the conventional treatment while minimizing the toxic effects and costs much less. This vaccine is currently managed by the Institute of Biomedicine, therefore any information regarding this treatment and its distribution is managed by them. This treatment has also been implemented in parts of South America and Central America.

¿What should I do if I suspect I have Leishmaniasis?

Contact your physician. If you live in the countryside you can ask for the nearest Sanitary Dermatology Service to be examined by their specialists. If you live close to the metropolitan area, you can go to the Institute of Biomedicine Dr. Jacinto Convit to get immediate assistance.

REGIONAL HEALTH SERVICES DERMATOLOGY (UPDATED JUNE 2016)

Amazonas

Service Address Coordinator Phone E-Mail
Puerto Ayacucho Av. Perimetral Cerro Orinoco CAICET Dr. Carlos Botto 0248-212223

Anzoátegui

Service Address Coordinator Phone E-Mail
Barcelona Hospital Luis Razetti, Servicio de Dermatología frente a Central de citas 1er piso. Dra. Pastora Helena Villarroel 0281-2687140
(Consultorio Privado)
0416-6805120
dravillaelena@hotmail.com
dermatología.sanitaria.anz@gmail.com
Dra. María Angélica Rojas 0414-8243441
0426-9830981
mariaangelica.rojas@gmail.com
Dr. Jhonny Saballo 0416-4805665 saballoj_2009@hotmail.com
Dra. Zulay Almao 0414-3819767 z_u_lyzuly@hotmail.com
Enfermera:
Shirly Carvajal
0416-3219463

Apure

Service Address Coordinator Phone E-Mail
San Fernando de Apure Hospital General Pablo Acosta Ortiz Av. Caracas, Servicio de Dermatología Dr. Víctor García 0414-2482228 victorgv855@gmail.com
Dr. Neudo Matos 0424-3586431 nempmedicomix@gmail.com

Aragua

Service Address Coordinator Phone E-Mail
Maracay Hospital Civil, Servicio de Dermatología, calle Brión entre Bolívar y Miranda frente a la Plaza Bolívar Dr. José Tapia 0243-2327054 (SDS)
0414-4568977
joseluistapiaporras@gmail.com
dermatologiasanitariaaragua@gmail.com
Dr. Atencio 0414-4622881 jomiatencio@gmail.com
Insp. Rosa Lovera 0414-4510588 coquimbo2@hotmail.com
Insp. Marlene León 0424-3299059

Barinas

Service Address Coordinator Phone E-Mail
Barinas Servicio de Salud Pública, Dermatología Sanitaria, calle Miranda con San Luis Dr. Ángel Cardozo 0414-5692208 dr.angelcardozo@gmail.com
Dr. Tomaso Marchetta 0414-5670460 tmarchetta8@hotmail.com

Bolívar

Service Address Coordinator Phone E-Mail
C. Bolívar Urbanización El Perú, Módulo El Perú, 1er piso Servicio de Dermatología Sanitaria Av. Dra. Rosaura Benítez 0424-9163691 rosaurayesares@hotmail.com
San Félix Centro Ambulatorio Manoa Servicio de Dermatología Av. Antonio de Berrios, frente al Colegio Fátima cerca al Terminal
Santa Elena de Uairen Dra. Aura María Suarez Gimon 0416-9691138 auras1305@yahoo.com

Carabobo

Service Address Coordinator Phone E-Mail
Valencia Hospital Rafael González Plaza servicio de dermatología sanitaria Barbula-Naguanagua Dr. Eusebio Plasencia 0241-9894924 (SDS)
0414-0407270
eusebioplasencia@hotmail.com
eusebioplasencia@gmail.com
Insp. José A. García 0416-7353008 chinogarcia1966@hotmail.com

Cojedes

Service Address Coordinator Phone E-Mail
San Carlos Ambulatorio Augusto Malave Villalba Servicio de Dermatología Sanitaria Av. Ricauter al lado de la Ferretería San Rafael “La Morena” Dr. Juan José Parra 0426-5445424 jjuanparrac@hotmail.com

Falcón

Service Address Coordinator Phone E-Mail
Coro Hospital Universitario de Coro, Servicio de Dermatología Sanitaria calle el Tenis PB Dra. Carmen Gutiérrez 0426-5830908
0414-6834204
carmenluisa64@yahoo.es
Insp. Alexis Clemant 0412-3841404 alex_clemant@hotmail.com

Guárico

Service Address Coordinator Phone E-Mail
San Juan de Los Morros Hospital Israel Raunares Balza, Servicio de Dermatología, Módulo 1 Dr. Alexis Castrillo 0414-1460560 alexis_castrillo@hotmail.com
Dr. Germán Hernández 0424-3034030 germanarpacuatroymaraca@hotmail.com
Insp. Gustavo Godoy 0412-4175556 gustavo_j17@hotmail.com
Directora Regional de Epidemiologia Lic. Evelyn Mijares 0414-5897072 elmi2114@gmail.com
miel021@hotmail.com
Dra. Yadexil Carbay 0424-3628212 yadeuc@yahoo.es
Zaraza Dr. Robert López/td> 0412-4102325 robertamado@gmail.com
Calabozo Hospital Francisco Torrealba, Servicio de Dermatología Sanitaria, Calle Libertad con Sixto Sosa Dr. Edy Silva 0416-6433041 gmperez@hotmail.com

Lara

Service Address Coordinator Phone E-Mail
Barquisimeto Dermatología Sanitaria Av. Las Palmas esquina Andrés Bello, entrada estacionamiento externo del Hospital Pediátrico Dra. Iraida Mendoza 0416-3541291 yayita55_5@hotmail.com
adermatologiasanitarialara@hotmail.com
Dra. Dorila Delgado 0414-5251976 doris_460@hotmail.com
Insp. Sandry Herrera 0414-0571233 sandryoskr@hotmail.com

Mérida

Service Address Coordinator Phone E-Mail
Mérida Hospital Universitario de los Andes, Servicio de Dermatología Sanitaria Dra. Amalia Vielma 0274-2403233 (SDS) amaliavielma@hotmail.com
Tovar Módulo de Servicio Las Acacias, Servicio de Dermatología. Sabaneta Dr. José Carrero 0275-8731216 (SDS)
0426-6878450
jcarrero1@gmail.com
El Vigía Centro de Salud del Vigía, Servicio de Dermatología Fundación Hospital Dos Dra. Dali González 0275-8813111 (SDS) dermatologiasanitariavigia@gmail.com
g.darli1909@yahoo.es

Miranda

Service Address Coordinator Phone E-Mail
Los Teques Hospital Victorino Santaella Servicio de Dermatología piso 5 Av. Bicentenaria vía el tambor Dra. Zoraida Zapata 0424-1398160 zorazapata@hotmail.com
zorazapata@gmail.com
Araira Ambulatorio Almirante Brión. Calle Pedro Camejo. Municipio Zamora. Edo. Miranda. Dra. Aribel Cedeño. (Araira) 0424-1333835 aribelc@gmail.com
San José Barlovento Sede del Distrito Sanitario N° 5 Servicio de Dermatología final Av. Bolívar con calle la Línea Dr. José Guevara 0414-3995091
0426-8045045
drmonra@hotmail.com
drmonra@yahoo.com

Monagas

Service Address Coordinator Phone E-Mail
Maturín Hospital general José Antonio Serres, Servicio de Dermatología, Zona Industrial Las Cocuizas Dra. Marelys Rodríguez 0424-9588792 marelyslrodriguez@gmail.com
Insp. María Josefina Fuente 0412-9964039 mariajosefina1003@yahoo.es
Insp. Lennin Salinas leninsalinas8@gmail.com

Nueva Esparta

Service Address Coordinator Phone E-Mail
Porlamar Calle Virgen del Valle, Ambulatorio José Asunción Rodríguez, Ciudad Cartón, Porlamar Dr. Melquíades Moreno 0416-6956773 melquiadesmoreno@gmail.com
dermatologianuevaesparta@gmail.com

Portuguesa

Service Address Coordinator Phone E-Mail
Guanare Av. Mariscal Sucre entrada al Aeropuerto. Servicio de Dermatología Sanitaria Dr. Pablo Moffi
Servicio
04264528700
0257-2517565
mofficatti@hotmail.com
Biscucuy Ambulatorio Diego Briceño, Servicio de Dermatología Dr. Pablo Moffi 04264528700 mofficatti@hotmail.com

Sucre

Service Address Coordinator Phone E-Mail
Cumaná Ambulatorio Arquímedes Serrano, Servicio de Dermatología Av. Perimetral Dr. Simón Decena
Secretaria Sonia Zapata
0412-9412911
0412-8794610
simondecena-ccudo@hotmail.com
delvallerodriguez12@gmail.com
Dr. José López 0414-8391125
0414-8026313
lopezway@hotmail.com
Dra. Betzabeth Arteaga 0426-3857658 betzarteaga@hotmail.com
betzarteaga@gmail.com
Insp. Daniel Castañeda dacastanedavivenez@gmail.com
Carúpano Hospital de Carúpano Servicio de Dermatología Av. Universitaria Dr. Jorge Maldonado 0412-0911928
0294-4052768
Directo SDSR
jmaldonadob19@yahoo.com
jmaldonadob57@gmail.com

Táchira

Service Address Coordinator Phone E-Mail
San Cristóbal Edificio de Malariología diagonal a la UNET Av. Universidad Pueblo Nuevo entre los Bomberos Universitarios y la Emisora Universitaria entrada alterna Barrio el Lobo. Dra. Xiomara Manrique 0416-0790585 xiomaramanrique@hotmail.com
dermatologiasanitariasc@gmail.com
Dr. Jonás Pérez 0414-1341863 cljonas_77@hotmail.com
Colon Urbanización Los Chinatos Av. Primera N° 0-31 Para retirar en las Oficinas de MRW calle 7 con carrera 5 Dr. José Molina 0424-7100627 dermatologiasanitariacolon@gmail.com
Insp. Audio 0416-1327481
Insp Barrio 0414-7155588
Insp Andy Pérez 0426-2762114
Insp Henry Mora 0416-6197342
Enfermera: María 0426-9786158
Secretaria Brigite Caballero (solo recibe correspondencia del SDS) 0426-6722769 brigitegenial970@hotmail.com
Lic. Elizabeth Díaz 0416-4772531
La Grita Dentro de las Instalaciones del Hospital Dr. Carlos Roa Moreno, al lado de la farmacia popular, Servicio de Dermatología Sanitaria Dr. José Plata 0277-8811241(Hab.)
0416-1783101
joseangelplata@gmail.com

Trujillo

Service Address Coordinator Phone E-Mail
Trujillo Sede de la Unidad Sanitaria Servicio de Dermatología piso 1 frente al Hospital José Gregorio Hernández. Dr. Rafael Castellanos 0414-7238206 rafacastellanos58@hotmail.com
Betijoque Distrito Sanitario N° 4 Dermatología Sanitaria Av.1 calle el Carmen, al lado de la Escuela Diego Bustillo Castellanos Dra. Moraima Montilla 0416-3677825 mora_367@hotmail.com
Bocono Unidad Sanitaria Servicio de Dermatología Sanitaria, Av. Rotari cruce con Av. Los Leones. Dr. Martín Berti 0414-0796591 ponceluisa@gmail.com
(correo de su esposa)
Aida Marin (Enfermera) 0416-0781593
Valera Hospital Central Pedro Emilio Carrillo, Servicio de Dermatología Sanitaria, al lado de Traumatología Dr. Víctor Zambrano 0416-8714946 dr.vzambrano@hotmail.com
Secretaria: Karla Valecillos 0424-7241476 carlavalecillos@hotmail.com

Vargas

Service Address Coordinator Phone E-Mail
La Guaira Servicio de Dermatología Sanitaria Centro Ambulatorio del SAS Av. Soublette Dtto. 6 NO HAY MEDICO

Yaracuy

Service Address Coordinator Phone E-Mail
San Felipe Servicio de Dermatología Sanitaria Av. La Patria entre 3ra y 4ta Avenida Dra. Angela Hamilton 0414-5466115
0412-6928177
angelamercury2009@hotmail.com
angelahamiltonmercury@gmail.com

Zulia

Service Address Coordinator Phone E-Mail
Maracaibo Calle 96, Sector el Transito, Antigua Unidad Sanitaria, Ambulatorio Francisco Gómez Padrón, Servicio de Dermatología, Sector el Transito 0261-7235506 (SDS) coordregdszulia@gmail.com
Dra. Zoila Barboza 0414-6400442 s7barboza@gmail.com
soyla7@hotmail.com
Sta. Bárbara Hospital General del Zulia Sta. Barbara. SD.


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