Fundación Jacinto Convit

Cancer


Introduction

Cancer is one of the major public health problems worldwide and is currently considered the second cause of death after cardiovascular diseases. In Venezuela, between 45,000 and 50,000 new cases each year have been reported (not including skin cancer cases) of which over 20,000 resulted in death, which makes cancer in Venezuela one of the primary causes of morbidity and mortality. Until recently, prostate and cervical cancer were the most common cancers observed in men and women respectively; however, now the number of breast cancer cases has increased rapidly and it is estimated that within a few years this type of cancer will overtake cervical cancer. Statistics show that globally there are 1.38 million new cases of breast cancer each year, and 458,000 deaths, making it the most frequent in women, in developed and developing countries.

Dr. Convit's Studies in Cancer

In 2003, Dr. Convit at the Institute of Biomedicine, began the first studies on a treatment based on immunotherapy for breast cancer and a few cases for colon, stomach and brain, which was documented in 2006 in the Official Medical Journal of Venezuela. (http://publicaciones.jacintoconvit.com/2006/?i=art2)

This proposal aims to stimulate the patient's immune response in order to activate the cell proliferation and elimination of the tumor cells. For the time being, this immunotherapy is experimental and continues under the process of validation.

The Role of the Foundation

The Jacinto Convit Foundation mainly works to continue the scientific protocol that Dr. Convit began in cancer immunotherapy more than a decade ago. Additionally, it is developing a program that can contribute to the prior step of treatment, which is to offer an early, more precise and personalized diagnosis of the disease. Therefore the Foundation has established two main objectives:

  1. Perform validation of the experimental studies in animal models with the immunotherapy treatment developed by Dr. Convit. This study is based in the induction of primary tumors in experimental animals, and the use of the therapy to induce immunological cellular responses that are more aggressive against tumor cells. These studies are being coordinated with the Jose Maria Vargas Medical School of the Central University of Venezuela.

  2. Establish a Molecular Diagnosis Unit based on conventional and cutting edge molecular techniques (i.e. pyrosequencing) to make a significant contribution to the diagnosis and prognostics for the different types of pediatric cancers, as well as the child's susceptibility to the treatment. This platform is being developed with the collaboration of the Children's Hospital JM de los Rios and the SANA Civil Association, as well as other institutions and donors.

Information for Patients

¿What is cancer?

Cancer is a term used to describe diseases in which abnormal cells divide uncontrollably and can invade other tissues. Cancer cells can spread to other parts of the body through the bloodstream and lymphatic system. There are presently more than 100 different types of cancer, most of which take on the name of the organ or cell in which it develops. For example, the cancer that develops in the mammary glands is called breast cancer while the cancer that develops in the colon is called colon cancer.

¿How does cancer develop?

Cancer originates in normal cells in the body. Normal cells multiply continuously, fulfilling a programmed and orderly cycle of growth, development and death. During this cycle the cells must go through different checkpoints. Cellular checkpoints are mechanisms that ensure the constancy of cell division, verifying whether the processes in each stage of the cell cycle have been accurately completed before progressing to the next stage. Many checkpoints have been identified. Cancer happens when the control and regulation of the cell cycle is lost, generating an uncontrolled growth of cells in the body which divide too quickly. It can also occur when cells that should be eliminated from the body don't go through the cell death stage and continue to multiply constantly.

Cancer is the uncontrolled growth of abnormal cells in the body, where a normal cell turns into an altered cell and develops in what is known as a tumor cell. During this process which develops in stages, the tumor cells begin to grow in a rapid and uncontrolled manner, overstepping their boundaries and capable of invading adjacent parts of the initial organ or spreading to other organs, a process known as metastasis. Metastases are the major cause of cancer-related deaths. In some cases, cancer cells can spread to other parts of the body through the bloodstream and lymphatic system.

The cause of transformation of a cell to a cancer cell is generally due to an alteration or genetic mutation (DNA), that is never repaired and with the ability to divide itself, generating new cells that have the same DNA alteration. In most cases, these cancer cells form a tumor, although some types of cancer such as leukemia rarely form tumors.

¿What causes cancer?

Cells undergo alterations caused by a set of interacting factors, such as patient-specific factors (genetic predisposition, age, ethnicity, geographic location, etc.) and environmental factors (food, tobacco and alcohol consumption, chemical food additives, pollution, medications and therapy, infections, etc). Tobacco and alcohol consumption, a poor diet and physical inactivity are the main risk factors for cancer in the world.

Cancer can arise spontaneously and in response to a chemical, physical (mutagenic substance) or biological agent (infectious agent). Among the mutagens are: physical agents (X-rays, ionizing radiation, etc.) and chemical agents (alkylating agents, aromatic amines, etc.). Some examples of biological agents are the human papilloma virus and bacteria such as Helicobacter pylori, among others.

¿Is there treatment for cancer?

A variety of cancer treatments are currently available. However, the application and type of treatment varies according to the type of cancer and its stage. The stage of a cancer refers to how much it has grown and to whether the cancer cells have spread or not from their original location. If the cancer is confined to one spot and has not spread, the most common treatment is to remove the tumor by surgery. Cancer cells that have spread to local lymph glands can also be removed by this method. If, however, the cancer cannot be completed removed by surgery, treatment options include radiation, chemotherapy or a combination of both. Some cancers require a combination of surgery, radiation and chemotherapy. Lymphomas (lymph node cancer) are rarely treated with surgery; chemotherapy and radiation therapy are most often applied to treat this type of cancer.

Although chemotherapy and radiotherapy are the main cancer treatments applied, in the past several years the use of immunotherapy has been proposed as an alternative treatment. This therapy is being widely studied worldwide and considered as the biggest scientific breakthrough of the year by the prestigious Journal of Science in 2013 (http://news.sciencemag.org/breakthrough-of-the-year-2013). In recent reports, immunotherapy has been described as the new era for cancer treatment that has a completely different approach to traditional treatments, because it targets the immune system of the patient to stimulate it, instead of targeting the tumor only.

Presently, there are many types of immunotherapy, all aimed at eliminating cancer cells. Among these are:

  • Monoclonal Antibodies: which are a type of protein produced in the laboratory that can bind to specific proteins of cancer cells (generally absent in normal cells), triggering the destruction of the cancer cell due to the patient's own immune system.

  • Non-specific immunotherapies: these activate the overall immunological system to induce the destruction of the cancer cells. Most non-specific immunotherapies are administered after or simultaneously with other cancer treatments such as chemotherapy or radiotherapy.

  • Vaccines: they expose a protein (antigen) to the immune system activating it and allowing it to recognize and destroy that specific protein or related cells. For cancer cases there are two types of vaccines, one for prevention, applied to someone without symptoms to avoid the developments of the disease; and one for treatment, that helps the immune system to attack the disease, helping it identify the cancer cells in order to destroy them and avoid recurrence of the disease.

¿How can morbidity and mortality caused by cancer be prevented?

Most cancers are most likely to be cured if detected early and treated properly. Over 30% of all cancer deaths could be prevented by modifying or avoiding key risk factors, such as tobacco and alcohol consumption, obesity, poor diet, physical inactivity and specific viral infections.

Prevention strategies

  • Vaccines for human papilloma virus (VHP) and hepatitis B virus (HBV)

  • Monitoring of occupational risks

  • Reduction of direct exposure to sunlight.

  • Prevention of the major risk factors above

Early Detection

Cancer mortality can be reduced if cases are detected and treated early. Early detection activities have two components:

  • Early diagnosis: Knowledge of the signs and symptoms (as in cervix, breast or mouth cancers) facilitates the diagnosis and treatment before the disease reaches an advanced stage. Early diagnosis programs are particularly important in underprivileged communities where most cases are diagnosed in advanced stages and there are no screening programs.

  • Screening: It is the systematic application of screening tests in an asymptomatic population in order to identify those patients who have abnormalities indicative of a specific cancer or precancerous lesions so they can be diagnosed and treated early. Screening programs are especially effective in the case of common cancers for which there are cost-effective, affordable, and acceptable tests for the majority of the population at risk.

¿Can children get cancer?

Yes, they can. Childhood cancer or pediatric cancer is cancer in children and young people. It's important to point out that when cancer affects a child or young person, it does so differently than in adults. A child with cancer must be accurately diagnosed and treated by a team of specialists in pediatric oncology. In most cases, there is a better prognosis in childhood cancer than in adults. Therefore, it is essential that all children have access to adequate treatment at the right time.

The most common cancers in children and adolescents are Leukemias (blood cancers) and solid tumors in the brain and central nervous system. Each cancer behaves differently, but they all have one common characteristic: the uncontrolled proliferation of abnormal cells.

REGIONAL HEALTH SERVICES DERMATOLOGY (UPDATED JUNE 2016)

Amazonas

Service Address Coordinator Phone E-Mail
Puerto Ayacucho Av. Perimetral Cerro Orinoco CAICET Dr. Carlos Botto 0248-212223

Anzoátegui

Service Address Coordinator Phone E-Mail
Barcelona Hospital Luis Razetti, Servicio de Dermatología frente a Central de citas 1er piso. Dra. Pastora Helena Villarroel 0281-2687140
(Consultorio Privado)
0416-6805120
dravillaelena@hotmail.com
dermatología.sanitaria.anz@gmail.com
Dra. María Angélica Rojas 0414-8243441
0426-9830981
mariaangelica.rojas@gmail.com
Dr. Jhonny Saballo 0416-4805665 saballoj_2009@hotmail.com
Dra. Zulay Almao 0414-3819767 z_u_lyzuly@hotmail.com
Enfermera:
Shirly Carvajal
0416-3219463

Apure

Service Address Coordinator Phone E-Mail
San Fernando de Apure Hospital General Pablo Acosta Ortiz Av. Caracas, Servicio de Dermatología Dr. Víctor García 0414-2482228 victorgv855@gmail.com
Dr. Neudo Matos 0424-3586431 nempmedicomix@gmail.com

Aragua

Service Address Coordinator Phone E-Mail
Maracay Hospital Civil, Servicio de Dermatología, calle Brión entre Bolívar y Miranda frente a la Plaza Bolívar Dr. José Tapia 0243-2327054 (SDS)
0414-4568977
joseluistapiaporras@gmail.com
dermatologiasanitariaaragua@gmail.com
Dr. Atencio 0414-4622881 jomiatencio@gmail.com
Insp. Rosa Lovera 0414-4510588 coquimbo2@hotmail.com
Insp. Marlene León 0424-3299059

Barinas

Service Address Coordinator Phone E-Mail
Barinas Servicio de Salud Pública, Dermatología Sanitaria, calle Miranda con San Luis Dr. Ángel Cardozo 0414-5692208 dr.angelcardozo@gmail.com
Dr. Tomaso Marchetta 0414-5670460 tmarchetta8@hotmail.com

Bolívar

Service Address Coordinator Phone E-Mail
C. Bolívar Urbanización El Perú, Módulo El Perú, 1er piso Servicio de Dermatología Sanitaria Av. Dra. Rosaura Benítez 0424-9163691 rosaurayesares@hotmail.com
San Félix Centro Ambulatorio Manoa Servicio de Dermatología Av. Antonio de Berrios, frente al Colegio Fátima cerca al Terminal
Santa Elena de Uairen Dra. Aura María Suarez Gimon 0416-9691138 auras1305@yahoo.com

Carabobo

Service Address Coordinator Phone E-Mail
Valencia Hospital Rafael González Plaza servicio de dermatología sanitaria Barbula-Naguanagua Dr. Eusebio Plasencia 0241-9894924 (SDS)
0414-0407270
eusebioplasencia@hotmail.com
eusebioplasencia@gmail.com
Insp. José A. García 0416-7353008 chinogarcia1966@hotmail.com

Cojedes

Service Address Coordinator Phone E-Mail
San Carlos Ambulatorio Augusto Malave Villalba Servicio de Dermatología Sanitaria Av. Ricauter al lado de la Ferretería San Rafael “La Morena” Dr. Juan José Parra 0426-5445424 jjuanparrac@hotmail.com

Falcón

Service Address Coordinator Phone E-Mail
Coro Hospital Universitario de Coro, Servicio de Dermatología Sanitaria calle el Tenis PB Dra. Carmen Gutiérrez 0426-5830908
0414-6834204
carmenluisa64@yahoo.es
Insp. Alexis Clemant 0412-3841404 alex_clemant@hotmail.com

Guárico

Service Address Coordinator Phone E-Mail
San Juan de Los Morros Hospital Israel Raunares Balza, Servicio de Dermatología, Módulo 1 Dr. Alexis Castrillo 0414-1460560 alexis_castrillo@hotmail.com
Dr. Germán Hernández 0424-3034030 germanarpacuatroymaraca@hotmail.com
Insp. Gustavo Godoy 0412-4175556 gustavo_j17@hotmail.com
Directora Regional de Epidemiologia Lic. Evelyn Mijares 0414-5897072 elmi2114@gmail.com
miel021@hotmail.com
Dra. Yadexil Carbay 0424-3628212 yadeuc@yahoo.es
Zaraza Dr. Robert López/td> 0412-4102325 robertamado@gmail.com
Calabozo Hospital Francisco Torrealba, Servicio de Dermatología Sanitaria, Calle Libertad con Sixto Sosa Dr. Edy Silva 0416-6433041 gmperez@hotmail.com

Lara

Service Address Coordinator Phone E-Mail
Barquisimeto Dermatología Sanitaria Av. Las Palmas esquina Andrés Bello, entrada estacionamiento externo del Hospital Pediátrico Dra. Iraida Mendoza 0416-3541291 yayita55_5@hotmail.com
adermatologiasanitarialara@hotmail.com
Dra. Dorila Delgado 0414-5251976 doris_460@hotmail.com
Insp. Sandry Herrera 0414-0571233 sandryoskr@hotmail.com

Mérida

Service Address Coordinator Phone E-Mail
Mérida Hospital Universitario de los Andes, Servicio de Dermatología Sanitaria Dra. Amalia Vielma 0274-2403233 (SDS) amaliavielma@hotmail.com
Tovar Módulo de Servicio Las Acacias, Servicio de Dermatología. Sabaneta Dr. José Carrero 0275-8731216 (SDS)
0426-6878450
jcarrero1@gmail.com
El Vigía Centro de Salud del Vigía, Servicio de Dermatología Fundación Hospital Dos Dra. Dali González 0275-8813111 (SDS) dermatologiasanitariavigia@gmail.com
g.darli1909@yahoo.es

Miranda

Service Address Coordinator Phone E-Mail
Los Teques Hospital Victorino Santaella Servicio de Dermatología piso 5 Av. Bicentenaria vía el tambor Dra. Zoraida Zapata 0424-1398160 zorazapata@hotmail.com
zorazapata@gmail.com
Araira Ambulatorio Almirante Brión. Calle Pedro Camejo. Municipio Zamora. Edo. Miranda. Dra. Aribel Cedeño. (Araira) 0424-1333835 aribelc@gmail.com
San José Barlovento Sede del Distrito Sanitario N° 5 Servicio de Dermatología final Av. Bolívar con calle la Línea Dr. José Guevara 0414-3995091
0426-8045045
drmonra@hotmail.com
drmonra@yahoo.com

Monagas

Service Address Coordinator Phone E-Mail
Maturín Hospital general José Antonio Serres, Servicio de Dermatología, Zona Industrial Las Cocuizas Dra. Marelys Rodríguez 0424-9588792 marelyslrodriguez@gmail.com
Insp. María Josefina Fuente 0412-9964039 mariajosefina1003@yahoo.es
Insp. Lennin Salinas leninsalinas8@gmail.com

Nueva Esparta

Service Address Coordinator Phone E-Mail
Porlamar Calle Virgen del Valle, Ambulatorio José Asunción Rodríguez, Ciudad Cartón, Porlamar Dr. Melquíades Moreno 0416-6956773 melquiadesmoreno@gmail.com
dermatologianuevaesparta@gmail.com

Portuguesa

Service Address Coordinator Phone E-Mail
Guanare Av. Mariscal Sucre entrada al Aeropuerto. Servicio de Dermatología Sanitaria Dr. Pablo Moffi
Servicio
04264528700
0257-2517565
mofficatti@hotmail.com
Biscucuy Ambulatorio Diego Briceño, Servicio de Dermatología Dr. Pablo Moffi 04264528700 mofficatti@hotmail.com

Sucre

Service Address Coordinator Phone E-Mail
Cumaná Ambulatorio Arquímedes Serrano, Servicio de Dermatología Av. Perimetral Dr. Simón Decena
Secretaria Sonia Zapata
0412-9412911
0412-8794610
simondecena-ccudo@hotmail.com
delvallerodriguez12@gmail.com
Dr. José López 0414-8391125
0414-8026313
lopezway@hotmail.com
Dra. Betzabeth Arteaga 0426-3857658 betzarteaga@hotmail.com
betzarteaga@gmail.com
Insp. Daniel Castañeda dacastanedavivenez@gmail.com
Carúpano Hospital de Carúpano Servicio de Dermatología Av. Universitaria Dr. Jorge Maldonado 0412-0911928
0294-4052768
Directo SDSR
jmaldonadob19@yahoo.com
jmaldonadob57@gmail.com

Táchira

Service Address Coordinator Phone E-Mail
San Cristóbal Edificio de Malariología diagonal a la UNET Av. Universidad Pueblo Nuevo entre los Bomberos Universitarios y la Emisora Universitaria entrada alterna Barrio el Lobo. Dra. Xiomara Manrique 0416-0790585 xiomaramanrique@hotmail.com
dermatologiasanitariasc@gmail.com
Dr. Jonás Pérez 0414-1341863 cljonas_77@hotmail.com
Colon Urbanización Los Chinatos Av. Primera N° 0-31 Para retirar en las Oficinas de MRW calle 7 con carrera 5 Dr. José Molina 0424-7100627 dermatologiasanitariacolon@gmail.com
Insp. Audio 0416-1327481
Insp Barrio 0414-7155588
Insp Andy Pérez 0426-2762114
Insp Henry Mora 0416-6197342
Enfermera: María 0426-9786158
Secretaria Brigite Caballero (solo recibe correspondencia del SDS) 0426-6722769 brigitegenial970@hotmail.com
Lic. Elizabeth Díaz 0416-4772531
La Grita Dentro de las Instalaciones del Hospital Dr. Carlos Roa Moreno, al lado de la farmacia popular, Servicio de Dermatología Sanitaria Dr. José Plata 0277-8811241(Hab.)
0416-1783101
joseangelplata@gmail.com

Trujillo

Service Address Coordinator Phone E-Mail
Trujillo Sede de la Unidad Sanitaria Servicio de Dermatología piso 1 frente al Hospital José Gregorio Hernández. Dr. Rafael Castellanos 0414-7238206 rafacastellanos58@hotmail.com
Betijoque Distrito Sanitario N° 4 Dermatología Sanitaria Av.1 calle el Carmen, al lado de la Escuela Diego Bustillo Castellanos Dra. Moraima Montilla 0416-3677825 mora_367@hotmail.com
Bocono Unidad Sanitaria Servicio de Dermatología Sanitaria, Av. Rotari cruce con Av. Los Leones. Dr. Martín Berti 0414-0796591 ponceluisa@gmail.com
(correo de su esposa)
Aida Marin (Enfermera) 0416-0781593
Valera Hospital Central Pedro Emilio Carrillo, Servicio de Dermatología Sanitaria, al lado de Traumatología Dr. Víctor Zambrano 0416-8714946 dr.vzambrano@hotmail.com
Secretaria: Karla Valecillos 0424-7241476 carlavalecillos@hotmail.com

Vargas

Service Address Coordinator Phone E-Mail
La Guaira Servicio de Dermatología Sanitaria Centro Ambulatorio del SAS Av. Soublette Dtto. 6 NO HAY MEDICO

Yaracuy

Service Address Coordinator Phone E-Mail
San Felipe Servicio de Dermatología Sanitaria Av. La Patria entre 3ra y 4ta Avenida Dra. Angela Hamilton 0414-5466115
0412-6928177
angelamercury2009@hotmail.com
angelahamiltonmercury@gmail.com

Zulia

Service Address Coordinator Phone E-Mail
Maracaibo Calle 96, Sector el Transito, Antigua Unidad Sanitaria, Ambulatorio Francisco Gómez Padrón, Servicio de Dermatología, Sector el Transito 0261-7235506 (SDS) coordregdszulia@gmail.com
Dra. Zoila Barboza 0414-6400442 s7barboza@gmail.com
soyla7@hotmail.com
Sta. Bárbara Hospital General del Zulia Sta. Barbara. SD.


Jacinto Convit Foundation - RIF J-40111708-2
Powered by
Nexus Radical